20. Natasha Lyonne
This actress’s comeback as a gritty, jailed up lesbian on Orange is the New Black is poignant in light of her own well-known and real-life struggles with (past?) drug addiction.
21. Mickey Rourke
After getting on the Hollywood “it boy” map in the 80s with Body Heat this actor spent 14 years away from the entertainment business, only to come back in 2008 as The Wrestler, which blew our minds.
