WHAT IS HPV? According to the CDC, the genital papillomavirus is the most common sexually transmitted infection. The infection is viral and there are more than 40 HPVs that can affect the genital area and the anus. Moreover, HPV can also affect the mouth and the throat. Most people who have this infection do not know they have it; which is why it is so easily spread. HPV is passed through vaginal, anal and oral sex and it can be spread even when there are no symptoms. It is also possible to spread more than one type of HPV.