Think about the recipe. For dips and sauces, go with Greek yogurt or crème fraîche. For baked goods, buttermilk or cream cheese works best because they add moisture and structure.
For cold dishes (like on tacos or nachos), use anything thick and tangy—Greek yogurt is king here. For hot dishes (stews, stroganoffs), avoid thin substitutes like buttermilk unless you thicken them first.
A good rule of thumb: the tangier, the better. Sour cream’s whole personality is “sour” and “creamy.” So replicate that vibe. If your swap has both, you’re golden.