In a study of 12,986 people published in Circulation, those with the highest levels of anger had twice the risk of coronary artery disease and three times the risk of heart attack. Anger triggers the release of stress hormones into the body, with a wide spectrum of negative effects. Findings like these have led public health experts like Laura Kubzansky, PhD, MPH, of Harvard University School of Public Health to say anger might be more damaging to health than obesity or smoking.