Cooking meatloaf at 350°F is like baking a giant, savory brownie. You wouldn’t bake brownies at 500°F, right? The outside would be a dark brick while the inside stays gooey (which is great for brownies, but dangerous for meat).
Or, think of it as a campfire story. The slow, steady heat of 350°F lets the flavors—onion, garlic, Worcestershire—mingle and build character. A blazing temp would just scorch the tale before it’s told. You want a story that takes its time.