Do not, under any circumstances, Flex a rookie running back on a team with a terrible offensive line. That’s like asking a hamster to pull a dump truck. You will get dust.
Avoid the “boom or bust” star who scored four touchdowns last year, all in one fluke game. That was a statistical glitch, not a trend. The fantasy universe hates your hope. It will laugh at your hope.
Also, never Flex a tight end unless his name is Travis Kelce, George Kittle, or Mark Andrews. Every other tight end is basically a very tall traffic cone who occasionally catches a pass. The Flex is for scoring, not for hoping your traffic cone remembers how to run a route.