4) THE GREAT SMOKY MOUNTAINS This is a famous southern road-trip. Take the 469-mile Blue Ridge Parkway that stretches along the Appalachian Mountains, connecting Shenandoah National Park and Great Smoky Mountains National Park. Many people brag about hiking the Appalachian Trail, but for most of us, driving it is just as awesome, especially in the fall when the mountainsides are ablaze with autumn colors. The drive takes you from the eclectic mountain town of Asheville, North Carolina to beautiful Waynesboro, Virginia. The Blue Ridge Parkway has it’s own website and app to help you plan your trip.